Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon eques
Joint Authors
Yunis Aguinaga, Jefferson
Claudiano, Gustavo S.
Marcusso, Paulo F.
Ikefuti, Cynthia
Ortega, George G.
Eto, Silas F.
da Cruz, Claudinei
Moraes, Juliet R. E.
Moraes, Flávio R.
Fernandes, João B. K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Uncaria tomentosa is a medicinal plant used in folk medicine by Amazon tribes.
In this study the constituents of aqueous extract of U.
tomentosa bark were quantified by chromatographic technique and its lethal concentration 50 (48 h) in Hyphessobrycon eques was determined.
The chromatography showed high levels of oxindole alkaloids, quinovic acid glycosides, and low molecular weight polyphenols.
The CL50 48 h was 1816 mg/L.
Fish showed behavior changes at concentrations above 2000 mg/L, accompanied by a significant decrease of dissolved oxygen.
At the highest concentration 100% mortality was observed attributed to oxygen reduction by the amount of oxindole alkaloids, polyphenols accumulation of the extract in the gills, and the interaction of these compounds with dopamine.
In conclusion, the aqueous extract of U.
tomentosa did not alter the chemical components and it was shown that U.
tomentosa has low toxicity to H.
eques; therefore, it can be used safely in this species.
American Psychological Association (APA)
Yunis Aguinaga, Jefferson& Claudiano, Gustavo S.& Marcusso, Paulo F.& Ikefuti, Cynthia& Ortega, George G.& Eto, Silas F.…[et al.]. 2014. Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon eques. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043193
Modern Language Association (MLA)
Yunis Aguinaga, Jefferson…[et al.]. Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon eques. Journal of Toxicology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043193
American Medical Association (AMA)
Yunis Aguinaga, Jefferson& Claudiano, Gustavo S.& Marcusso, Paulo F.& Ikefuti, Cynthia& Ortega, George G.& Eto, Silas F.…[et al.]. Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon eques. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043193