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Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleifera Leaves
Joint Authors
Asiedu-Gyekye, I. J.
Frimpong-Manso, S.
Awortwe, C.
Antwi, D. A.
Nyarko, Alexander
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Moringa oleifera is a multipurpose plant used in Ghana and most parts of Africa.
Its high mineral, protein, and vitamins content has enabled its use as a nutraceutical and panacea for various diseases.
This study aimed at measuring the micro- and macroelements content of dried Moringa oleifera leaves using energy dispersive X-ray fluorescence spectroscopic (EDXRF) and assessing its toxicological effect in rats.
Acute toxicity (5000 mg/kg) and a subacute toxicity studies of the leaf (40 mg/kg to 1000 mg/kg) extract were conducted in rats.
Blood samples were assessed for biochemical and haematological parameters.
Results showed significant levels of thirty-five (35) elements (14 macroelements and 21 microelements) in M.
oleifera extract.
There were no observed overt adverse reactions in the acute and subacute studies.
Although there were observed elevations in liver enzymes ALT and ALP (P<0.001) and lower creatinine levels in the extract treated groups, no adverse histopathological findings were found.
Moringa oleifera dried leaf extract may, therefore, be reasonably safe for consumption.
However, the consumption of Moringa oleifera leaves should not exceed a maximum of 70 grams per day to prevent cumulative toxicity of these essential elements over long periods.
American Psychological Association (APA)
Asiedu-Gyekye, I. J.& Frimpong-Manso, S.& Awortwe, C.& Antwi, D. A.& Nyarko, Alexander. 2014. Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleifera Leaves. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043212
Modern Language Association (MLA)
Asiedu-Gyekye, I. J.…[et al.]. Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleifera Leaves. Journal of Toxicology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043212
American Medical Association (AMA)
Asiedu-Gyekye, I. J.& Frimpong-Manso, S.& Awortwe, C.& Antwi, D. A.& Nyarko, Alexander. Micro- and Macroelemental Composition and Safety Evaluation of the Nutraceutical Moringa oleifera Leaves. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043212