Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
Joint Authors
Hosseinimehr, Seyed Jalal
Hosseini, Seyed Amir Hossein
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by 131I in thyroid cancer cell.
Methods.
Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with 131I and/or resveratrol at different concentrations for 48 h.
The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Results.
Findings of this study show that resveratrol enhanced the cell death induced by 131I on thyroid cancer cell.
Also, resveratrol exhibited a protective effect on normal cells against 131I toxicity.
Conclusion.
This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy.
American Psychological Association (APA)
Hosseinimehr, Seyed Jalal& Hosseini, Seyed Amir Hossein. 2014. Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043213
Modern Language Association (MLA)
Hosseinimehr, Seyed Jalal& Hosseini, Seyed Amir Hossein. Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity. Journal of Toxicology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043213
American Medical Association (AMA)
Hosseinimehr, Seyed Jalal& Hosseini, Seyed Amir Hossein. Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043213