The Toxic Effect of Manganese on the Acetylcholinesterase Activity in Rat Brains
Joint Authors
Reazai, Mohammad
Yousefi Babadi, Vahid
Sadeghi, Leila
Shirani, Kobra
Malekirad, Ali Akbar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Manganese (Mn) is a naturally occurring element and an essential nutrient for humans and animals.
However, exposure to high levels of Mn may cause neurotoxic effects.
Accumulation of manganese damages central nervous system and causes Parkinson’s disease-like syndrome called manganism.
Mn neurotoxicity has been suggested to involve an imbalance between the DAergic and cholinergic systems.
The pathological mechanisms associated with Mn neurotoxicity are poorly understood, but several reports have established it is mediated by changing of AChE activity that resulted in oxidative stress.
Therefore we focused the effect of Mn in AChE activity in the rat’s brain by MnCl2 injection intraperitoneally and analyzed their brains after time intervals.
This study used different acute doses in short time course and different chronic doses at different exposing time to investigate which of them (exposing dose or time) is more important in Mn toxic effect.
Results showed toxic effect of Mn is highly dose dependent and AChE activity in presence of chronic dose in 8 weeks reaches acute dose in only 2 days.
American Psychological Association (APA)
Yousefi Babadi, Vahid& Sadeghi, Leila& Shirani, Kobra& Malekirad, Ali Akbar& Reazai, Mohammad. 2014. The Toxic Effect of Manganese on the Acetylcholinesterase Activity in Rat Brains. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1043221
Modern Language Association (MLA)
Yousefi Babadi, Vahid…[et al.]. The Toxic Effect of Manganese on the Acetylcholinesterase Activity in Rat Brains. Journal of Toxicology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1043221
American Medical Association (AMA)
Yousefi Babadi, Vahid& Sadeghi, Leila& Shirani, Kobra& Malekirad, Ali Akbar& Reazai, Mohammad. The Toxic Effect of Manganese on the Acetylcholinesterase Activity in Rat Brains. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1043221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043221