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Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts.
In acute toxicity study, no mortality or any toxic reaction was recorded in any group after 14 days of administering the extracts (2000 mg Kg−1 BW).
The extracts (ALA, ABA, ALM, and ABM) did not cause any behavioural or physical changes in experimental rats.
There was no significant (P≤0.05) difference in the biochemical parameters analysed between the groups.
Slight elevation in activities of AST and ALT in extract treated groups was observed, but this did not exert any deleterious effect on the normal metabolism which was supported by the histopathology of liver.
Histopathological studies showed no remarkable changes after 14 days of oral administration of ALA, ABA, ALM, and ABM extracts.
The study contributes to establishing the nontoxic quality parameters of Artocarpus altilis leaf and bark parts and the results suggest the safety of the extracts in therapeutic uses.
American Psychological Association (APA)
Sairam, Sudha& Urooj, Asna. 2014. Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043222
Modern Language Association (MLA)
Sairam, Sudha& Urooj, Asna. Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats. Journal of Toxicology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043222
American Medical Association (AMA)
Sairam, Sudha& Urooj, Asna. Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043222