![](/images/graphics-bg.png)
Strategies to Overcome Antileishmanial Drugs Unresponsiveness
Joint Authors
Sundar, Shyam
Singh, Anup
Singh, Om Prakash
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In the absence of effective vector control measures and vaccines against leishmaniasis, effective chemotherapy remains the mainstay of treatment.
As the armoury of antileishmanial drugs is limited, strategies should be made to target the emergence of drug resistance.
The loss of efficacy of antimonials such as sodium stibogluconate in the Indian subcontinent which has been the mainstay of treatment for more than six decades has raised concern to save the other drugs.
In the current review, we highlight various steps which could be implemented to halt the increasing unresponsiveness of drugs such as monitoring of therapy in the form of rational dosing and duration of treatment, understanding the mechanism of action of the drugs and drug resistance, identification of markers of resistance, distribution of drugs free of cost, evolution of effective combination therapy and immunotherapy, and proper management of HIV/VL coinfection and post-kala-azar dermal leishmaniasis (PKDL).
Strong support from governmental agencies and local communities in the form of education and orientation programmes for feasibility of implementing these strategies and affordability within the context of their health systems is needed in controlling and preventing leishmaniasis.
American Psychological Association (APA)
Sundar, Shyam& Singh, Anup& Singh, Om Prakash. 2014. Strategies to Overcome Antileishmanial Drugs Unresponsiveness. Journal of Tropical Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043241
Modern Language Association (MLA)
Sundar, Shyam…[et al.]. Strategies to Overcome Antileishmanial Drugs Unresponsiveness. Journal of Tropical Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043241
American Medical Association (AMA)
Sundar, Shyam& Singh, Anup& Singh, Om Prakash. Strategies to Overcome Antileishmanial Drugs Unresponsiveness. Journal of Tropical Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043241