Occult Hepatitis B Virus Infection among HIV Positive Patients in Nigeria
Joint Authors
Ojurongbe, Olusola
Opaleye, Oluyinka Oladele
Oluremi, Adeolu Sunday
Atiba, Adetona Babatunde
Adewumi, Moses Olubusuyi
Mabayoje, Olatunji Victor
Donbraye, Emmanuel
Olowe, O. Adekunle
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
HIV has been known to interfere with the natural history of hepatitis B virus (HBV) infection.
In this study we investigate the prevalence of occult hepatitis B virus infection (OBI) among HIV-infected individuals in Nigeria.
Overall, 1200 archived HIV positive samples were screened for detectable HBsAg using rapid technique, in Ikole Ekiti Specialist Hospital.
The HBsAg negative samples were tested for HBsAg, anti-HBc, and anti-HCV by ELISA.
Polymerase chain reaction was used for HBV DNA amplification and CD4 counts were analyzed by cytometry.
Nine hundred and eighty of the HIV samples were HBsAg negative.
HBV DNA was detected in 21/188 (11.2%) of patients without detectable HBsAg.
CD4 count for the patients ranged from 2 to 2,140 cells/ μL of blood (mean = 490 cells/ μL of blood).
HCV coinfection was detected only in 3/188 (1.6%) of the HIV-infected patients ( P > 0.05 ).
Twenty-eight (29.2%) of the 96 HIV samples screened were positive for anti-HBc.
Averagely the HBV viral load was <50 copies/mL in the OBI samples examined by quantitative PCR.
The prevalence of OBI was significantly high among HIV-infected patients.
These findings highlight the significance of nucleic acid testing in HBV diagnosis in HIV patients.
American Psychological Association (APA)
Opaleye, Oluyinka Oladele& Oluremi, Adeolu Sunday& Atiba, Adetona Babatunde& Adewumi, Moses Olubusuyi& Mabayoje, Olatunji Victor& Donbraye, Emmanuel…[et al.]. 2014. Occult Hepatitis B Virus Infection among HIV Positive Patients in Nigeria. Journal of Tropical Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043246
Modern Language Association (MLA)
Opaleye, Oluyinka Oladele…[et al.]. Occult Hepatitis B Virus Infection among HIV Positive Patients in Nigeria. Journal of Tropical Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043246
American Medical Association (AMA)
Opaleye, Oluyinka Oladele& Oluremi, Adeolu Sunday& Atiba, Adetona Babatunde& Adewumi, Moses Olubusuyi& Mabayoje, Olatunji Victor& Donbraye, Emmanuel…[et al.]. Occult Hepatitis B Virus Infection among HIV Positive Patients in Nigeria. Journal of Tropical Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043246