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Effectiveness and Safety of Concurrent Use of First-Line Antiretroviral and Antituberculous Drugs in Rwanda
Joint Authors
Kadima, Justin Ntokamunda
Mukanyangezi, Marie Françoise
Uwizeye, Claude Bernard
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Overlapping toxicity between drugs used for HIV and TB could complicate the management of HIV/TB coinfected patients, particularly those carrying multiple opportunistic infections.
This study aimed to evaluate the clinical outcomes and adverse drug events in HIV patients managed with first-line antiretroviral and first-line anti-TB drugs.
Methods.
This is a retrospective study utilizing medical dossiers from single-HIV infected and HIV/TB coinfected patients already initiated on ART.
Predictors of outcomes included changes in CD4 cells/mm3, body weight, physical improvement, death rate, and adverse drug reactions.
Results.
Records from 60 HIV patients and 60 HIV/TB patients aged between 20 and 58 years showed that all clinical indicators of effectiveness were better in single-HIV infected than in HIV/TB coinfected patients: higher CD4 cell counts, better physical improvement, and low prevalence of adverse drug events.
The most frequently prescribed regimen was TDF/3TC/EFV+RHZE.
The mortality rate was 20% in HIV/TB patients compared to 8.3% in the single-HIV group.
Conclusion.
Treatment regimens applied are efficient in controlling the progression of the infection.
However, attention should be paid to adjust dosing when combining nonnucleoside antiretrovirals (EFV and NVR) with anti-TB drugs to minimize the risk of death by drug intoxication.
American Psychological Association (APA)
Kadima, Justin Ntokamunda& Mukanyangezi, Marie Françoise& Uwizeye, Claude Bernard. 2014. Effectiveness and Safety of Concurrent Use of First-Line Antiretroviral and Antituberculous Drugs in Rwanda. Journal of Tropical Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043251
Modern Language Association (MLA)
Kadima, Justin Ntokamunda…[et al.]. Effectiveness and Safety of Concurrent Use of First-Line Antiretroviral and Antituberculous Drugs in Rwanda. Journal of Tropical Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043251
American Medical Association (AMA)
Kadima, Justin Ntokamunda& Mukanyangezi, Marie Françoise& Uwizeye, Claude Bernard. Effectiveness and Safety of Concurrent Use of First-Line Antiretroviral and Antituberculous Drugs in Rwanda. Journal of Tropical Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043251