Preablation Stimulated ThyroglobulinTSH Ratio as a Predictor of Successful I131Remnant Ablation in Patients with Differentiated Thyroid Cancer following Total Thyroidectomy
Joint Authors
Zubair Hussain, Syed
Zaman, Maseeh uz
Malik, Sarwar
Ram, Nanik
Asghar, Ali
Rabbani, Unaib
Aftab, Nida
Islam, Najmul
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
About 90% of thyroid cancers are differentiated thyroid cancers.
Standard treatment is total thyroidectomy followed by radioactive I131remnant ablation and TSH suppression with thyroxine.
Unsuccessful ablation drastically affects the prognosis of patients with DTC particularly high risk individuals; therefore, identifying the factors that affect the success of ablation is important in the management of patients with DTC.
sTg is a good predictor of successful ablation in DTC.
Its levels can be influenced by tumor staging and TSH values, as well as other factors.
Therefore, we did this study using TSH to correct the predictive value of sTg in success of RRA.
Methods.
We retrospectively reviewed the records of 75 patients with DTC, who underwent total thyroidectomy followed by RRA and TSH suppression.
Results.
Preablation sTg and sTg/TSH ratio are significantly associated with ablation outcome.
Cutoff value for sTg to predict successful and unsuccessful ablation was 18 ng/mL with 76.7% sensitivity and 79.1% specificity, while for sTg/TSH cutoff was 0.35 with 81.4% sensitivity and 81.5% specificity (P<0.001).
Association was stronger for sTg/TSH ratio with adjusted odds ratio (AOR) 11.64 (2.43–55.61) than for sTg with AOR 5.42 (1.18–24.88).
Conclusions.
Preablation sTg/TSH ratio can be considered as better predictor of ablation outcome than sTg, tumor size, and capsular invasion.
American Psychological Association (APA)
Zubair Hussain, Syed& Zaman, Maseeh uz& Malik, Sarwar& Ram, Nanik& Asghar, Ali& Rabbani, Unaib…[et al.]. 2014. Preablation Stimulated ThyroglobulinTSH Ratio as a Predictor of Successful I131Remnant Ablation in Patients with Differentiated Thyroid Cancer following Total Thyroidectomy. Journal of Thyroid Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043265
Modern Language Association (MLA)
Zubair Hussain, Syed…[et al.]. Preablation Stimulated ThyroglobulinTSH Ratio as a Predictor of Successful I131Remnant Ablation in Patients with Differentiated Thyroid Cancer following Total Thyroidectomy. Journal of Thyroid Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043265
American Medical Association (AMA)
Zubair Hussain, Syed& Zaman, Maseeh uz& Malik, Sarwar& Ram, Nanik& Asghar, Ali& Rabbani, Unaib…[et al.]. Preablation Stimulated ThyroglobulinTSH Ratio as a Predictor of Successful I131Remnant Ablation in Patients with Differentiated Thyroid Cancer following Total Thyroidectomy. Journal of Thyroid Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043265