Thyrotoxic Periodic Paralysis: Clinical Challenges
Joint Authors
Ashwath, Giridhar
Thimmappa, Durganna
Vijayakumar, Abhishek
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis.
The condition primarily affects the lower extremities and is secondary to thyrotoxicosis.
The underlying hyperthyroidism is often subtle causing difficulty in early diagnosis.
Factors like high-carbohydrate meal exercise, steroid, and stress can precipitate an attack of TPP.
Evidence is building up showing role of genetic mutations in Kir2.6 channel in the pathogenesis of TPP.
Loss of function of Kir2.6 together with increased activity of Na+/K+ ATPase may trigger a positive feed-forward cycle of hypokalemia.
Biochemical hyperthyroidism with normal urinary potassium excretion and ECG changes are characteristic of TPP.
Treatment with low-dose potassium supplements and nonselective beta-blockers should be initiated upon diagnosis, and the serum potassium level should be frequently monitored to prevent rebound hyperkalemia.
American Psychological Association (APA)
Vijayakumar, Abhishek& Ashwath, Giridhar& Thimmappa, Durganna. 2014. Thyrotoxic Periodic Paralysis: Clinical Challenges. Journal of Thyroid Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043267
Modern Language Association (MLA)
Vijayakumar, Abhishek…[et al.]. Thyrotoxic Periodic Paralysis: Clinical Challenges. Journal of Thyroid Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043267
American Medical Association (AMA)
Vijayakumar, Abhishek& Ashwath, Giridhar& Thimmappa, Durganna. Thyrotoxic Periodic Paralysis: Clinical Challenges. Journal of Thyroid Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043267