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Differential Profile of Ultrasound Findings Associated with Malignancy in Mixed and Solid Thyroid Nodules in an Elderly Female Population
Joint Authors
Vera, María Inés
Meroño, Tomás
Urrutia, María Agustina
Parisi, Carina
Morosan, Yanina
Rosmarin, Melanie
Schnitman, Marta
Brites, Fernando
Grisendi, Silvio
Serrano, María Sol
Luciani, Wilfredo
Serrano, Leonardo
Zuk, Carlos
De Barrio, Guillermo
Cejas, Claudia
Faingold, María Cristina
Brenta, Gabriela
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Ultrasonographic characteristics are associated with thyroid malignancy.
Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules.
Methods.
We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy.
Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo.
Associations were separately assessed in mixed and solid nodules.
Results.
In a group of 504 elderly female patients (age = 69±8 years), the frequency of malignant cytology was 6%.
Thirty-one percent of nodules were mixed and 60% were solid.
The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, P: 0.56).
While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all P<0.05).
The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25–6.10), P: 0.012).
Conclusions.
Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules.
Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules.
American Psychological Association (APA)
Vera, María Inés& Meroño, Tomás& Urrutia, María Agustina& Parisi, Carina& Morosan, Yanina& Rosmarin, Melanie…[et al.]. 2014. Differential Profile of Ultrasound Findings Associated with Malignancy in Mixed and Solid Thyroid Nodules in an Elderly Female Population. Journal of Thyroid Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043270
Modern Language Association (MLA)
Vera, María Inés…[et al.]. Differential Profile of Ultrasound Findings Associated with Malignancy in Mixed and Solid Thyroid Nodules in an Elderly Female Population. Journal of Thyroid Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043270
American Medical Association (AMA)
Vera, María Inés& Meroño, Tomás& Urrutia, María Agustina& Parisi, Carina& Morosan, Yanina& Rosmarin, Melanie…[et al.]. Differential Profile of Ultrasound Findings Associated with Malignancy in Mixed and Solid Thyroid Nodules in an Elderly Female Population. Journal of Thyroid Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043270