Impact of Maternal Thyroperoxidase Status on Fetal Body and Brain Size
Joint Authors
Salihu, Hamisu M.
Groer, Maureen
Wilson, Roneé E.
O’Rourke, Kathleen
Mbah, Alfred K.
Dagne, Getachew A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The obstetric consequences of abnormal thyroid function during pregnancy have been established.
Less understood is the influence of maternal thyroid autoantibodies on infant outcomes.
The objective of this study was to examine the influence of maternal thyroperoxidase (TPO) status on fetal/infant brain and body growth.
Six-hundred thirty-one (631) euthyroid pregnant women were recruited from prenatal clinics in Tampa Bay, Florida, and the surrounding area between November 2007 and December 2010.
TPO status was determined during pregnancy and fetal/infant brain and body growth variables were assessed at delivery.
Regression analysis revealed maternal that TPO positivity was significantly associated with smaller head circumference, reduced brain weight, and lower brain-to-body ratio among infants born to TPO+ white, non-Hispanic mothers only, distinguishing race/ethnicity as an effect modifier in the relationship.
No significant differences were noted in body growth measurements among infants born to TPO positive mothers of any racial/ethnic group.
Currently, TPO antibody status is not assessed as part of the standard prenatal care laboratory work-up, but findings from this study suggest that fetal brain growth may be impaired by TPO positivity among certain populations; therefore autoantibody screening among high-risk subgroups may be useful for clinicians to determine whether prenatal thyroid treatment is warranted.
American Psychological Association (APA)
Wilson, Roneé E.& Salihu, Hamisu M.& Groer, Maureen& Dagne, Getachew A.& O’Rourke, Kathleen& Mbah, Alfred K.. 2014. Impact of Maternal Thyroperoxidase Status on Fetal Body and Brain Size. Journal of Thyroid Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043273
Modern Language Association (MLA)
Wilson, Roneé E.…[et al.]. Impact of Maternal Thyroperoxidase Status on Fetal Body and Brain Size. Journal of Thyroid Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043273
American Medical Association (AMA)
Wilson, Roneé E.& Salihu, Hamisu M.& Groer, Maureen& Dagne, Getachew A.& O’Rourke, Kathleen& Mbah, Alfred K.. Impact of Maternal Thyroperoxidase Status on Fetal Body and Brain Size. Journal of Thyroid Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043273