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Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis
Joint Authors
Texidó, Laura
Romero, Claudia
Vidal, August
García-Valero, José
Fernández Montoli, M. Eulalia
Baixeras, Núria
Condom, Enric
Ponce, Jordi
García-Tejedor, Amparo
Martín-Satué, Mireia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide.
It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic pain, and infertility being the main characteristics.
Ovarian endometriomas are frequently developed in women with endometriosis.
Late diagnosis is one of the main problems of endometriosis; thus, it is important to identify biomarkers for early diagnosis.
The aim of the present work is to evaluate the ecto-nucleotidases activities in the contents of endometriomas.
These enzymes, through the regulation of extracellular ATP and adenosine levels, are key enzymes in inflammatory processes, and their expression has been previously characterized in human endometrium.
To achieve our objective, the echo-guided aspirated fluids of endometriomas were analyzed by evaluating the ecto-nucleotidases activities and compared with simple cysts.
Our results show that enzyme activities are quantifiable in the ovarian cysts aspirates and that endometriomas show significantly higher ecto-nucleotidases activities than simple cysts (5.5-fold increase for ATPase and 20-fold for ADPase), thus being possible candidates for new endometriosis biomarkers.
Moreover, we demonstrate the presence of ecto-nucleotidases bearing exosomes in these fluids.
These results add up to the knowledge of the physiopathologic mechanisms underlying endometriosis and, open up a promising new field of study.
American Psychological Association (APA)
Texidó, Laura& Romero, Claudia& Vidal, August& García-Valero, José& Fernández Montoli, M. Eulalia& Baixeras, Núria…[et al.]. 2014. Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043313
Modern Language Association (MLA)
Texidó, Laura…[et al.]. Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043313
American Medical Association (AMA)
Texidó, Laura& Romero, Claudia& Vidal, August& García-Valero, José& Fernández Montoli, M. Eulalia& Baixeras, Núria…[et al.]. Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043313