Myeloperoxidase Oxidized LDL Interferes with Endothelial Cell Motility through miR-22 and Heme Oxygenase 1 Induction: Possible Involvement in Reendothelialization of Vascular Injuries
Joint Authors
Daher, Jalil
Martin, Maud
Rousseau, Alexandre
Nuyens, Vincent
Fayyad-Kazan, Hussein
Courbebaisse, Guy
Martiat, Philippe
Badran, Bassam
Dequiedt, Frank
Vanhamme, Luc
Van Antwerpen, Pierre
Zouaoui Boudjeltia, Karim
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cardiovascular disease linked to atherosclerosis is the leading cause of death worldwide.
Atherosclerosis is mainly linked to dysfunction in vascular endothelial cells and subendothelial accumulation of oxidized forms of LDL.
In the present study, we investigated the role of myeloperoxidase oxidized LDL (Mox-LDL) in endothelial cell dysfunction.
We studied the effect of proinflammatory Mox-LDL treatment on endothelial cell motility, a parameter essential for normal vascular processes such as angiogenesis and blood vessel repair.
This is particularly important in the context of an atheroma plaque, where vascular wall integrity is affected and interference with its repair could contribute to progression of the disease.
We investigated in vitro the effect of Mox-LDL on endothelial cells angiogenic properties and we also studied the signalling pathways that could be affected by analysing Mox-LDL effect on the expression of angiogenesis-related genes.
We report that Mox-LDL inhibits endothelial cell motility and tubulogenesis through an increase in miR-22 and heme oxygenase 1 expression.
Our in vitro data indicate that Mox-LDL interferes with parameters associated with angiogenesis.
They suggest that high LDL levels in patients would impair their endothelial cell capacity to cope with a damaged endothelium contributing negatively to the progression of the atheroma plaque.
American Psychological Association (APA)
Daher, Jalil& Martin, Maud& Rousseau, Alexandre& Nuyens, Vincent& Fayyad-Kazan, Hussein& Van Antwerpen, Pierre…[et al.]. 2014. Myeloperoxidase Oxidized LDL Interferes with Endothelial Cell Motility through miR-22 and Heme Oxygenase 1 Induction: Possible Involvement in Reendothelialization of Vascular Injuries. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043325
Modern Language Association (MLA)
Daher, Jalil…[et al.]. Myeloperoxidase Oxidized LDL Interferes with Endothelial Cell Motility through miR-22 and Heme Oxygenase 1 Induction: Possible Involvement in Reendothelialization of Vascular Injuries. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043325
American Medical Association (AMA)
Daher, Jalil& Martin, Maud& Rousseau, Alexandre& Nuyens, Vincent& Fayyad-Kazan, Hussein& Van Antwerpen, Pierre…[et al.]. Myeloperoxidase Oxidized LDL Interferes with Endothelial Cell Motility through miR-22 and Heme Oxygenase 1 Induction: Possible Involvement in Reendothelialization of Vascular Injuries. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043325