Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy
Joint Authors
Wojciechowska, Celina
Romuk, Ewa
Tomasik, Andrzej
Skrzep-Poloczek, Bronisława
Nowalany-Kozielska, Ewa
Birkner, Ewa
Jacheć, Wojciech
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The aim of study was to determine relationships between functional capacity (NYHA class), left ventricle ejection fraction (LVEF), hemodynamic parameters, and biomarkers of redox state and inflammation in patients with dilated cardiomyopathy (DCM).
Methods.
DCM patients (n=109, aged 45.97±10.82 years), NYHA class IIV, and LVEF 2.94±7.1% were studied.
Controls comprised age-matched healthy volunteers (n=28).
Echocardiography and right heart catheterization were performed.
Serum activities of superoxide dismutase isoenzymes (MnSOD and CuZnSOD), concentrations of uric acid (UA), malondialdehyde (MDA), and C-reactive protein (hs-CRP) were measured.
Results.
MnSOD, UA, hs-CRP, and MDA were significantly higher in DCM patients compared to controls.
Except MDA concentration, above parameters were higher in patients in III-IV NYHA class or with lower LVEF.
hsCRP correlated with of MnSOD (P<0.05) and CuZnSOD activity (P<0.01).
Both isoenzymes positively correlated with mPAP and pulmonary capillary wedge pressure (MnSOD, resp., P<0.01 and P<0.05 and CuZnSOD P<0.05; P<0.05).
UA positively correlated with MnSOD (P<0.05), mPAP (P<0.05), and PVRI (P<0.05).
The negative correlation between LVEF and UA (P<0.01) was detected.
Conclusion.
There are relationships among the severity of symptoms of heart failure, echocardiographic hemodynamic parameters, oxidative stress, and inflammatory activation.
Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.
American Psychological Association (APA)
Wojciechowska, Celina& Romuk, Ewa& Tomasik, Andrzej& Skrzep-Poloczek, Bronisława& Nowalany-Kozielska, Ewa& Birkner, Ewa…[et al.]. 2014. Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043345
Modern Language Association (MLA)
Wojciechowska, Celina…[et al.]. Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043345
American Medical Association (AMA)
Wojciechowska, Celina& Romuk, Ewa& Tomasik, Andrzej& Skrzep-Poloczek, Bronisława& Nowalany-Kozielska, Ewa& Birkner, Ewa…[et al.]. Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043345