Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels
Joint Authors
Padilla-Gutiérrez, Jorge Ramón
Flores-Salinas, Hector Enrique
Valle, Yeminia
García-González, Ilian Janet
Valdés-Alvarado, Emmanuel
Sandoval-Pinto, Elena
Valdez-Haro, Angélica
Rivas, Fernando
Muñoz-Valle, José Francisco
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
The acute coronary syndrome (ACS) is a complex disease where genetic and environmental factors are involved.
E-selectin gene is a candidate for ACS progression due to its contribution in the inflammatory process and endothelial function.
The rs5361 (561A>C) polymorphism in the E-selectin gene has been linked to changes in gene expression, affinity for its receptor, and plasmatic levels; therefore it is associated with an increased risk of cardiovascular disease.
The aim of this study was to determine the association of the rs5361 polymorphism with ACS and to measure serum levels of soluble E-selectin (sE-selectin).
Materials and Methods.
283 ACS patients and 205 healthy subjects (HS) from Western Mexico were included.
The polymerase chain reaction-restriction fragment length polymorphism was used to determine the rs5361 polymorphism.
The sE-selectin levels were measured by enzyme-linked immunosorbent assay.
Results.
Neither genotype nor allele frequencies of the rs5361 polymorphism showed statistical differences between groups.
The sE-selectin levels were significantly higher in ACS patients compared to HS (54.58 versus 40.41 ng/ml, P=0.02).
The C allele had no effect on sE-selectin levels.
Conclusions.
The rs5361 E-selectin gene polymorphism is not a susceptibility marker for ACS in Western Mexico population.
However, sE-selectin may be a biological marker of ACS.
American Psychological Association (APA)
Sandoval-Pinto, Elena& Padilla-Gutiérrez, Jorge Ramón& Valdés-Alvarado, Emmanuel& García-González, Ilian Janet& Valdez-Haro, Angélica& Muñoz-Valle, José Francisco…[et al.]. 2014. Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043348
Modern Language Association (MLA)
Sandoval-Pinto, Elena…[et al.]. Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043348
American Medical Association (AMA)
Sandoval-Pinto, Elena& Padilla-Gutiérrez, Jorge Ramón& Valdés-Alvarado, Emmanuel& García-González, Ilian Janet& Valdez-Haro, Angélica& Muñoz-Valle, José Francisco…[et al.]. Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043348