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Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome
Joint Authors
Wu, Bang-wei
Lu, Zheng-de
Huang, Ying
Shi, Ying
Meng, Kai
Yu, Kunwu
Chai, Meng
Liu, Yuyang
Zhou, Yujie
Lin, Ying-zhong
Zeng, Qiu-tang
Ji, Qing-wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases.
However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated.
Methods.
Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients.
Results.
The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients.
A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP), N-terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF).
Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis.
Conclusions.
The results indicate that the plasma IL-37 levels are associated with the onset of ACS.
American Psychological Association (APA)
Ji, Qing-wei& Zeng, Qiu-tang& Huang, Ying& Shi, Ying& Lin, Ying-zhong& Lu, Zheng-de…[et al.]. 2014. Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043350
Modern Language Association (MLA)
Ji, Qing-wei…[et al.]. Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043350
American Medical Association (AMA)
Ji, Qing-wei& Zeng, Qiu-tang& Huang, Ying& Shi, Ying& Lin, Ying-zhong& Lu, Zheng-de…[et al.]. Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043350