![](/images/graphics-bg.png)
Generation of IL-8 and IL-9 Producing CD4+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands
Joint Authors
Gasch, Michaela
Goroll, Tina
Bauer, Mario
Hinz, Denise
Schütze, Nicole
Polte, Tobias
Kesper, Dörthe
Simon, Jan C.
Hackermüller, Jörg
Lehmann, Irina
Herberth, Gunda
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The T helper cell subsets Th1, Th2, Th17, and Treg play an important role in immune cell homeostasis, in host defense, and in immunological disorders.
Recently, much attention has been paid to Th17 cells which seem to play an important role in the early phase of the adoptive immune response and autoimmune disease.
When generating Th17 cells under in vitro conditions the amount of IL-17A producing cells hardly exceeds 20% while the nature of the remaining T cells is poorly characterized.
As engagement of the aryl hydrocarbon receptor (AHR) has also been postulated to modulate the differentiation of T helper cells into Th17 cells with regard to the IL-17A expression we ask how far do Th17 polarizing conditions in combination with ligand induced AHR activation have an effect on the production of other T helper cell cytokines.
We found that a high proportion of T helper cells cultured under Th17 polarizing conditions are IL-8 and IL-9 single producing cells and that AHR activation results in an upregulation of IL-8 and a downregulation of IL-9 production.
Thus, we have identified IL-8 and IL-9 producing T helper cells which are subject to regulation by the engagement of the AHR.
American Psychological Association (APA)
Gasch, Michaela& Goroll, Tina& Bauer, Mario& Hinz, Denise& Schütze, Nicole& Polte, Tobias…[et al.]. 2014. Generation of IL-8 and IL-9 Producing CD4+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043361
Modern Language Association (MLA)
Gasch, Michaela…[et al.]. Generation of IL-8 and IL-9 Producing CD4+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043361
American Medical Association (AMA)
Gasch, Michaela& Goroll, Tina& Bauer, Mario& Hinz, Denise& Schütze, Nicole& Polte, Tobias…[et al.]. Generation of IL-8 and IL-9 Producing CD4+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043361