Chemokines Profiling of Patients with Preterm Birth
Joint Authors
Laudanski, Piotr
Lemancewicz, Adam
Kuc, Pawel
Charkiewicz, Karol
Ramotowska, Barbara
Jasinska, Elwira
Raba, Grzegorz
Karwasik-Kajszczarek, Katarzyna
Kraczkowski, Janusz
Laudanski, Tadeusz
Krętowska, Małgorzata
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Nowadays it is thought that the main cause of premature birth is subclinical infection.
However, none of the currently used methods provide effective prevention to preterm labor.
The aim of the study was to determine the concentration of selected chemokines in sera of patients with premature birth without clinical signs of infection (n=62), threatened preterm labor (n=47), and term births (n=28).
Method.
To assess the concentration of chemokines in the blood serum, we used a multiplex method, which allows the simultaneous determination of 40 chemokines per sample.
The sets consist of the following chemokines: 6Ckine/CCL21, Axl, BTC, CCL28, CTACK/CCL27, CXCL16, ENA-78/CXCL5, Eotaxin-3/CCL26, GCP-2/CXC, GRO (GROα/CXCL1, GROβ/CXCL2 and GROγ/CXCL3), HCC-1/CCL14, HCC-4/CCL16, IL-9, IL-17F, IL18-BPa, IL-28A, IL-29, IL-31, IP-10/CXCL10, I-TAC/CXCL11, LIF, LIGHT/TNFSF14, Lymphotactin/XCL1, MCP-2/CCL8, MCP-3/CCL7, MCP-4/CCL13, MDC/CCL22, MIF, MIP-3α/CCL20, MIP-3-β/CCL19, MPIF-1/CCL23, NAP-2/CXCL7, MSPα, OPN, PARC/CCL18, PF4, SDF-1/CXCL12, TARC/CCL17, TECK/CCL25, and TSLP.
Results.
We showed possible implication of 4 chemokines, that is, HCC-4, I-TAC, MIP-3α, and TARC in women with symptoms of preterm delivery.
Conclusion.
On the basis of our findings, it seems that the chemokines may play role in the pathogenesis of preterm labor.
Defining their potential as biochemical markers of preterm birth requires further investigation on larger group of patients.
American Psychological Association (APA)
Laudanski, Piotr& Lemancewicz, Adam& Kuc, Pawel& Charkiewicz, Karol& Ramotowska, Barbara& Krętowska, Małgorzata…[et al.]. 2014. Chemokines Profiling of Patients with Preterm Birth. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043365
Modern Language Association (MLA)
Laudanski, Piotr…[et al.]. Chemokines Profiling of Patients with Preterm Birth. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043365
American Medical Association (AMA)
Laudanski, Piotr& Lemancewicz, Adam& Kuc, Pawel& Charkiewicz, Karol& Ramotowska, Barbara& Krętowska, Małgorzata…[et al.]. Chemokines Profiling of Patients with Preterm Birth. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043365