Decreased Expression of the Aryl Hydrocarbon Receptor in Ocular Behcet’s Disease
Joint Authors
Wang, Chaokui
Ye, Zi
Kijlstra, Aize
Zhou, Yan
Yang, Peizeng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recent studies show that the aryl hydrocarbon receptor (AhR) is involved in immune responses.
AhR is activated following interaction with its ligands, such as 6-formylindolo[3,2-b]carbazole (FICZ) and 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE).
In this study, we investigated the role of AhR activation by its endogenous ligands in the pathogenesis of ocular Behcet’s disease (BD).
The expression of AhR was significantly decreased in active BD patients as compared to inactive BD patients and normal controls.
Both FICZ and ITE inhibited Th1 and Th17 polarization and induced the expression of IL-22 by PBMCs and by CD4+T cells in active BD patients and normal controls.
Stimulation of purified CD4+T cells with FICZ or ITE caused a decreased expression of RORC, IL-17, IL-23R, and CCR6 and an increased phosphorylation of STAT3 and STAT5.
The present study suggests that a decreased AhR expression is associated with disease activity in BD patients.
The activation of AhR by either FICZ or ITE was able to inhibit Th1 and Th17 cell polarization.
Further studies are needed to investigate whether modulation of AhR might be used in the treatment of BD.
American Psychological Association (APA)
Wang, Chaokui& Ye, Zi& Kijlstra, Aize& Zhou, Yan& Yang, Peizeng. 2014. Decreased Expression of the Aryl Hydrocarbon Receptor in Ocular Behcet’s Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043369
Modern Language Association (MLA)
Wang, Chaokui…[et al.]. Decreased Expression of the Aryl Hydrocarbon Receptor in Ocular Behcet’s Disease. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043369
American Medical Association (AMA)
Wang, Chaokui& Ye, Zi& Kijlstra, Aize& Zhou, Yan& Yang, Peizeng. Decreased Expression of the Aryl Hydrocarbon Receptor in Ocular Behcet’s Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043369