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Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression
Joint Authors
Tao, Tianzhu
Deng, Xiaoming
Zhao, Yan-jun
Yi, Wen-jing
Wan, Xiao-jian
Wang, Jun
Wang, Jia-feng
Li, Jinbao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Intercellular adhesion molecule-1 (ICAM-1) is a key adhesion molecule mediating neutrophil migration and infiltration during sepsis.
But its role in the outcome of sepsis remains contradictory.
The current study was performed to investigate the role of anti-ICAM-1 antibody in the outcome of polymicrobial sepsis and sepsis-induced immune disturbance.
Effect of anti-ICAM-1 antibody on outcome of sepsis induced by cecal ligation and puncture (CLP) was evaluated by the survival analysis, bacterial clearance, and lung injury.
Its influence on neutrophil migration and infiltration, as well as lymphocyte status, in thymus and spleen was also investigated.
The results demonstrated that ICAM-1 mRNA was upregulated in lung, thymus, and spleen of CLP mice.
Anti-ICAM-1 antibody improved survival and bacterial clearance in CLP mice and attenuated lung injury.
Migration of neutrophils to peritoneal cavity was enhanced while their infiltration into lung, thymus, and spleen was hampered by ICAM-1 blockade.
Anti-ICAM-1 antibody also prevented sepsis-induced apoptosis in thymus and spleen.
Positive costimulatory molecules including CD28, CD80, and CD86 were upregulated, while negative costimulatory molecules including PD-1 and PD-L1 were downregulated following anti-ICAM-1 antibody administration.
In conclusion, ICAM-1 blockade may improve outcome of sepsis.
The rationale may include the modulated neutrophil migration and the reversed immunosuppression.
American Psychological Association (APA)
Zhao, Yan-jun& Yi, Wen-jing& Wan, Xiao-jian& Wang, Jun& Tao, Tianzhu& Li, Jinbao…[et al.]. 2014. Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043370
Modern Language Association (MLA)
Zhao, Yan-jun…[et al.]. Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043370
American Medical Association (AMA)
Zhao, Yan-jun& Yi, Wen-jing& Wan, Xiao-jian& Wang, Jun& Tao, Tianzhu& Li, Jinbao…[et al.]. Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043370