Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System

Joint Authors

de Souza, Cláudio T.
Irigoyen, Maria Cláudia
Lira, Fábio Santos
Caperuto, Erico Chagas
Rodrigues, Bruno
Santana, Aline Alves
Santamarina, Aline Boveto
Barboza, Catarina de Andrade
Rocha, Leandro Yanase
Figueroa, Diego
Mostarda, Cristiano
Oyama, Lila Missae

Source

Mediators of Inflammation

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-06-18

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

The aim of this study was to evaluate the effects of exercise training (ET, 50–70% of VO2 max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats.

Male Wistar rats were divided into control (C, n = 8 ), sedentary infarcted (SI, n = 9 ), trained infarcted (TI, n = 10 ; 3 months of ET), and detrained infarcted (DI, n = 11 ; 2 months of ET + 1 month of DT).

After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated.

ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue.

These positive changes were sustained even after 1 month of detraining.

No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups.

In conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI.

These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI.

American Psychological Association (APA)

Rodrigues, Bruno& Santana, Aline Alves& Santamarina, Aline Boveto& Oyama, Lila Missae& Caperuto, Erico Chagas& de Souza, Cláudio T.…[et al.]. 2014. Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043374

Modern Language Association (MLA)

Rodrigues, Bruno…[et al.]. Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043374

American Medical Association (AMA)

Rodrigues, Bruno& Santana, Aline Alves& Santamarina, Aline Boveto& Oyama, Lila Missae& Caperuto, Erico Chagas& de Souza, Cláudio T.…[et al.]. Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043374

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1043374