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YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints
Joint Authors
Moilanen, Teemu
Moilanen, Eeva
Vuolteenaho, Katriina
Väänänen, Tuija
Paukkeri, Erja-Leena
Hämäläinen, Mari
Koskinen, Anna
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
YKL-40 is associated with tissue injury and inflammation, and consequently to diseases in which these mechanisms lead to tissue degradation, for example, asthma and rheumatoid arthritis.
The purpose of the present study was to investigate if YKL-40 is also a significant factor in osteoarthritis (OA) by assessing associations of YKL-40 with mediators related to the pathogenesis of OA: cartilage destructing matrix metalloproteinases (MMPs) and proinflammatory cytokines interleukin-6 (IL-6) and interleukin-17 (IL-17).
Cartilage, synovial fluid (SF), and plasma samples were obtained from 100 OA patients undergoing total knee replacement surgery.
SF levels of YKL-40 (1027.9 ± 78.3 ng/mL) were considerably higher than plasma levels (67.2 ± 4.5 ng/mL) and correlated with YKL-40 released from cartilage samples obtained from the same patients (r=0.37, P=0.010), indicating that YKL-40 is produced by OA cartilage.
Interestingly, YKL-40 concentrations in OA SF correlated positively with MMP-1 (r=0.36, P=0.014), MMP-3 (r=0.46, P=0.001), IL-6 (r=0.57, P<0.001), and IL-17 (r=0.52, P=0.010) levels.
Moreover, IL-6 and IL-17 enhanced YKL-40 production in human primary chondrocyte cultures.
The present study introduces YKL-40 as a cartilage-derived factor associated with mediators of inflammation and cartilage destruction involved in the pathogenesis of OA.
American Psychological Association (APA)
Väänänen, Tuija& Koskinen, Anna& Paukkeri, Erja-Leena& Hämäläinen, Mari& Moilanen, Teemu& Moilanen, Eeva…[et al.]. 2014. YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043382
Modern Language Association (MLA)
Väänänen, Tuija…[et al.]. YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043382
American Medical Association (AMA)
Väänänen, Tuija& Koskinen, Anna& Paukkeri, Erja-Leena& Hämäläinen, Mari& Moilanen, Teemu& Moilanen, Eeva…[et al.]. YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043382