Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation
Joint Authors
Kido, Taketomo
Yoneda, Mitsuhiro
Cai, Yan
Matsubara, Tsutomu
Ward, Jerrold M.
Kimura, Shioko
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, which may play a role in lung inflammation, is predominantly expressed in airway epithelial cells.
In order to understand the physiological role of SCGB3A2, Scgb3a2−/− mice were generated and characterized.
Scgb3a2−/− mice did not exhibit any overt phenotypes.
In ovalbumin- (OVA-) induced airway allergy inflammation model, Scgb3a2−/− mice in mixed background showed a decreased OVA-induced airway inflammation, while six times C57BL/6NCr backcrossed congenic Scgb3a2−/− mice showed a slight exacerbation of OVA-induced airway inflammation as compared to wild-type littermates.
These results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property.
The results further suggest the possible use of recombinant human SCGB3A2 as an anti-inflammatory agent.
American Psychological Association (APA)
Kido, Taketomo& Yoneda, Mitsuhiro& Cai, Yan& Matsubara, Tsutomu& Ward, Jerrold M.& Kimura, Shioko. 2014. Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043385
Modern Language Association (MLA)
Kido, Taketomo…[et al.]. Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043385
American Medical Association (AMA)
Kido, Taketomo& Yoneda, Mitsuhiro& Cai, Yan& Matsubara, Tsutomu& Ward, Jerrold M.& Kimura, Shioko. Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043385