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Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum
Joint Authors
Costa, Carlos Henrique Nery
Goto, Hiro
Carvalho, Márcia Dias Teixeira
Alonso, Diego Peres
Vendrame, Célia Maria Vieira
Costa, Dorcas Lamounier
Werneck, Guilherme Loureiro
Ribolla, Paulo Eduardo Martins
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In visceral leishmaniasis (VL) endemic areas, a minority of infected individuals progress to disease since most of them develop protective immunity.
Therefore, we investigated the risk markers of VL within nonimmune sector.
Analyzing infected symptomatic and, asymptomatic, and noninfected individuals, VL patients presented with reduced high-density lipoprotein cholesterol (HDL-C), elevated triacylglycerol (TAG), and elevated very-low-density lipoprotein cholesterol (VLDL-C) levels.
A polymorphism analysis of the lipoprotein lipase (LPL) gene using HindIII restriction digestion (N = 156 samples) (H+ = the presence and H− = the absence of mutation) revealed an increased adjusted odds ratio (OR) of VL versus noninfected individuals when the H+/H+ was compared with the H−/H− genotype (OR = 21.3; 95% CI = 2.32–3335.3; P = 0.003).
The H+/H+ genotype and the H+ allele were associated with elevated VLDL-C and TAG levels (P < 0.05) and reduced HDL-C levels (P < 0.05).
An analysis of the L162V polymorphism in the peroxisome proliferator-activated receptor alpha (PPARα) gene (n = 248) revealed an increased adjusted OR when the Leu/Val was compared with the Leu/Leu genotype (OR = 8.77; 95% CI = 1.41–78.70; P = 0.014).
High TAG (P = 0.021) and VLDL-C (P = 0.023) levels were associated with susceptibility to VL, whereas low HDL (P = 0.006) levels with resistance to infection.
The mutated LPL and the PPARα Leu/Val genotypes may be considered risk markers for the development of VL.
American Psychological Association (APA)
Carvalho, Márcia Dias Teixeira& Alonso, Diego Peres& Vendrame, Célia Maria Vieira& Costa, Dorcas Lamounier& Costa, Carlos Henrique Nery& Werneck, Guilherme Loureiro…[et al.]. 2014. Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043392
Modern Language Association (MLA)
Carvalho, Márcia Dias Teixeira…[et al.]. Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043392
American Medical Association (AMA)
Carvalho, Márcia Dias Teixeira& Alonso, Diego Peres& Vendrame, Célia Maria Vieira& Costa, Dorcas Lamounier& Costa, Carlos Henrique Nery& Werneck, Guilherme Loureiro…[et al.]. Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043392