Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis
Joint Authors
Bordignon, Valentina
Chiricozzi, A.
Orlandi, Augusto
Bianchi, L.
Bonifati, C.
Ruzzetti, M.
Francesconi, F.
Bultrini, S.
Francavilla, V.
Tripiciano, A.
Campione, E.
Cavallotti, C.
Berardesca, E.
Cordiali-Fei, Paola
Ensoli, Fabrizio
Trento, Elisabetta
D'Agosto, Giovanna
Chimenti, Sergio
Di Carlo, Aldo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The therapeutic management of psoriasis includes conventional treatments as well as the new generation of highly effective TNF-α inhibitors.
However, psoriasis has proven to be a complex therapeutic challenge and treatment failures are not uncommon.
Thus, laboratory biomarkers of disease progression/therapeutic efficacy may greatly help in the clinical management of psoriasis.
Aims.
To identify laboratory biomarkers for clinical management and therapeutic monitoring of psoriasis.
Methods.
An observational study performed on 59 patients, presenting moderate to severe psoriasis, undergoing treatment with anti-TNF-α agents (etanercept, adalimumab, and infliximab).
Soluble and cellular immune/inflammatory parameters were assessed at baseline and after 12 and 24 weeks of treatment.
Results.
Clinical efficacy was achieved in 88% of the subjects at 12 weeks, reaching 90% after 24 weeks.
IL-6 and IL-22, which were elevated at baseline, were significantly reduced, in association with a significant decrease of CLA+ T cells and an increase of Treg lymphocytes.
T, B, and NK cell subsets and T cell response to recall antigens did not show any evidence of immune suppression.
Conclusions.
Immune/inflammatory parameters including IL-6 and IL-22, CLA+ T cells, and Treg lymphocytes may prove to be valuable laboratory tools for the clinical and therapeutic monitoring of psoriasis.
American Psychological Association (APA)
Cordiali-Fei, Paola& Bianchi, L.& Bonifati, C.& Trento, Elisabetta& Ruzzetti, M.& Francesconi, F.…[et al.]. 2014. Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043396
Modern Language Association (MLA)
Cordiali-Fei, Paola…[et al.]. Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043396
American Medical Association (AMA)
Cordiali-Fei, Paola& Bianchi, L.& Bonifati, C.& Trento, Elisabetta& Ruzzetti, M.& Francesconi, F.…[et al.]. Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043396