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CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?
Joint Authors
dos Santos Virgilio, Fernando
Pontes, Camila
Dominguez, Mariana Ribeiro
Ersching, Jonatan
Vasconcelos, José Ronnie
Rodrigues, Mauricio M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
MHC-restricted CD 8 + T cells are important during infection with the intracellular protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Experimental studies performed in the past 25 years have elucidated a number of features related to the immune response mediated by these T cells, which are important for establishing the parasite/host equilibrium leading to chronic infection.
CD 8 + T cells are specific for highly immunodominant antigens expressed by members of the trans-sialidase family.
After infection, their activation is delayed, and the cells display a high proliferative activity associated with high apoptotic rates.
Although they participate in parasite control and elimination, they are unable to clear the infection due to their low fitness, allowing the parasite to establish the chronic phase when these cells then play an active role in the induction of heart immunopathology.
Vaccination with a number of subunit recombinant vaccines aimed at eliciting specific CD 8 + T cells can reverse this path, thereby generating a productive immune response that will lead to the control of infection, reduction of symptoms, and reduction of disease transmission.
Due to these attributes, activation of CD 8 + T lymphocytes may constitute a path for the development of a veterinarian or human vaccine.
American Psychological Association (APA)
dos Santos Virgilio, Fernando& Pontes, Camila& Dominguez, Mariana Ribeiro& Ersching, Jonatan& Rodrigues, Mauricio M.& Vasconcelos, José Ronnie. 2014. CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043399
Modern Language Association (MLA)
dos Santos Virgilio, Fernando…[et al.]. CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043399
American Medical Association (AMA)
dos Santos Virgilio, Fernando& Pontes, Camila& Dominguez, Mariana Ribeiro& Ersching, Jonatan& Rodrigues, Mauricio M.& Vasconcelos, José Ronnie. CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043399