Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway
Joint Authors
Si, Yanhong
Zhang, Ying
Zhao, Jilong
Guo, Shoudong
Zhai, Lei
Yao, Shutong
Sang, Hui
Yang, Nana
Song, Guohua
Gu, Jue
Qin, Shucun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The study aimed to investigate the effect of niacin on vascular inflammatory lesions in vivo and in vitro as well as its lipid-regulating mechanism.
In vivo study revealed that niacin downregulated the levels of inflammatory factors (IL-6 and TNF-α) in plasma, suppressed protein expression of CD68 and NF-κB p65 in arterial wall, and attenuated oxidative stress in guinea pigs that have been fed high fat diet.
In vitro study further confirmed that niacin decreased the secretion of IL-6 and TNF-α and inhibited NF-κB p65 and notch1 protein expression in oxLDL-stimulated HUVECs and THP-1 macrophages.
Moreover, niacin attenuated oxLDL-induced apoptosis of HUVECs as well.
In addition, niacin significantly lessened lipid deposition in arterial wall, increased HDL-C and apoA levels and decreased TG and non-HDL-C levels in plasma, and upregulated the mRNA amount of cholesterol 7α-hydroxylase A1 in liver of guinea pigs.
These data suggest for the first time that niacin inhibits vascular inflammation in vivo and in vitro via downregulating NF-κB signaling pathway.
Furthermore, niacin also modulates plasma lipid by upregulating the expression of factors involved in the process of reverse cholesterol transport.
American Psychological Association (APA)
Si, Yanhong& Zhang, Ying& Zhao, Jilong& Guo, Shoudong& Zhai, Lei& Yao, Shutong…[et al.]. 2014. Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043410
Modern Language Association (MLA)
Si, Yanhong…[et al.]. Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043410
American Medical Association (AMA)
Si, Yanhong& Zhang, Ying& Zhao, Jilong& Guo, Shoudong& Zhai, Lei& Yao, Shutong…[et al.]. Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043410