Neonatal Sepsis and Inflammatory Mediators
Joint Authors
Corrêa, Rosana Rosa Miranda
Vinícius da Silva, Marcos
Monteiro, Maria Luiza Gonçalves dos Reis
Soave, Danilo Figueiredo
de Menezes, Liliana Borges
Etchebehere, Renata Margarida
Celes, Mara Rúbia Nunes
Reis, Marlene Antônia dos
Machado, Juliana Reis
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult.
The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics.
Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators.
Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur.
Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines.
Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival.
By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion.
American Psychological Association (APA)
Machado, Juliana Reis& Soave, Danilo Figueiredo& Vinícius da Silva, Marcos& de Menezes, Liliana Borges& Etchebehere, Renata Margarida& Monteiro, Maria Luiza Gonçalves dos Reis…[et al.]. 2014. Neonatal Sepsis and Inflammatory Mediators. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043412
Modern Language Association (MLA)
Machado, Juliana Reis…[et al.]. Neonatal Sepsis and Inflammatory Mediators. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043412
American Medical Association (AMA)
Machado, Juliana Reis& Soave, Danilo Figueiredo& Vinícius da Silva, Marcos& de Menezes, Liliana Borges& Etchebehere, Renata Margarida& Monteiro, Maria Luiza Gonçalves dos Reis…[et al.]. Neonatal Sepsis and Inflammatory Mediators. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043412