![](/images/graphics-bg.png)
Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses
Joint Authors
Yi, Young-Su
Kim, Jong-Hoon
Ryou, Chongsuk
Cho, Jae Youl
Sung, Gi-Ho
Son, Young-Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Inflammation is a series of complex biological responses to protect the host from pathogen invasion.
Chronic inflammation is considered a major cause of diseases, such as various types of inflammatory/autoimmune diseases and cancers.
Spleen tyrosine kinase (Syk) was initially found to be highly expressed in hematopoietic cells and has been known to play crucial roles in adaptive immune responses.
However, recent studies have reported that Syk is also involved in other biological functions, especially in innate immune responses.
Although Syk has been extensively studied in adaptive immune responses, numerous studies have recently presented evidence that Syk has critical functions in macrophage-mediated inflammatory responses and is closely related to innate immune response.
This review describes the characteristics of Syk-mediated signaling pathways, summarizes the recent findings supporting the crucial roles of Syk in macrophage-mediated inflammatory responses and diseases, and discusses Syk-targeted drug development for the therapy of inflammatory diseases.
American Psychological Association (APA)
Yi, Young-Su& Son, Young-Jin& Ryou, Chongsuk& Sung, Gi-Ho& Kim, Jong-Hoon& Cho, Jae Youl. 2014. Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043413
Modern Language Association (MLA)
Yi, Young-Su…[et al.]. Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043413
American Medical Association (AMA)
Yi, Young-Su& Son, Young-Jin& Ryou, Chongsuk& Sung, Gi-Ho& Kim, Jong-Hoon& Cho, Jae Youl. Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043413