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Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat
Joint Authors
Mohsenzadeh, Yosouf
Rahmani, Asghar
Cheraghi, Javad
Pyrani, Maryam
Asadollahi, Khairollah
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This study aimed to investigate any inflammatory effect of nicotine on rat embryo by exposing their mothers to different dosages of nicotine during pregnancy.
During this experimental study, 32 pregnant healthy Wistar rats were divided into 4 equal groups, including a control and 3 nicotine exposure groups.
Injections were performed subcutaneously starting at the first day of pregnancy until parturition.
As the dosages of nicotine were increased, the weight gain by pregnant rats and the mean weight of their newborns were significantly reduced.
Mean ± SD of hs-CRP was significantly higher among groups exposed to various dosages of nicotine (2, 4, and 6 mg/kg) compared to the control group ( P < 0.0001 ) and its increasing rate was also dose dependent.
Mean ± SD serum level of IL-6 and TNF- α among all groups exposed to nicotine, except for 2 mg/kg nicotine injected group, was increased significantly ( P < 0.0001 ).
Mean ± SD of serum level of TGF- β and nitrite oxide among exposure groups showed significant differences compared to the control group only at the dosage of 6 mg/kg ( P < 0.0001 ).
The current study showed that exposing pregnant rats to nicotine causes a dose dependent increase in the rate of all the studied inflammatory serum markers among their newborns.
American Psychological Association (APA)
Mohsenzadeh, Yosouf& Rahmani, Asghar& Cheraghi, Javad& Pyrani, Maryam& Asadollahi, Khairollah. 2014. Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043414
Modern Language Association (MLA)
Mohsenzadeh, Yosouf…[et al.]. Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat. Mediators of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043414
American Medical Association (AMA)
Mohsenzadeh, Yosouf& Rahmani, Asghar& Cheraghi, Javad& Pyrani, Maryam& Asadollahi, Khairollah. Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043414