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Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients
Joint Authors
Parolini, Marina
Verde, Alessandro
Botta, Luca
Cozzi, Lorena
Milazzo, Filippo
Nonini, Sandra
Martinelli, Luigi
Paino, Roberto
Marraccini, Paolo
Campolo, Jonica
Frigerio, Maria
Caruso, Raffaele
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The mechanical circulatory support (MCS) is an effective treatment in critically ill patients with end-stage heart failure (ESHF) that, however, may cause a severe multiorgan failure syndrome (MOFS) in these subjects.
The impact of altered inflammatory response, associated to MOFS, on clinical evolution of MCS postimplantation patients has not been yet clarified.
Methods.
Circulating cytokines, adhesion molecules, and a marker of monocyte activation (neopterin) were determined in 53 MCS-treated patients, at preimplant and until 2 weeks.
MOFS was evaluated by total sequential organ failure assessment score (tSOFA).
Results.
During MCS treatment, 32 patients experienced moderate MOFS (tSOFA < 11; A group), while 21 patients experienced severe MOFS (tSOFA ≥ 11) with favorable (B group) or adverse ( n = 13 , C group) outcomes.
At preimplant, higher values of left ventricular ejection fraction (LVEF) and estimated glomerular filtration rate (eGFR) were the only parameter independently associated with A group.
In C group, during the first postoperative week, high levels of interleukin-8 (IL-8) and tumor necrosis factor (TNF)-α, and an increase of neopterin and adhesion molecules, precede tSOFA worsening and exitus.
Conclusions.
The MCS patients of C group show an excessive release to IL-8 and TNF-α, and monocyte-endothelial activation after surgery, that might contribute to the unfavourable evolution of severe MOFS.
American Psychological Association (APA)
Caruso, Raffaele& Campolo, Jonica& Verde, Alessandro& Botta, Luca& Cozzi, Lorena& Parolini, Marina…[et al.]. 2014. Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043417
Modern Language Association (MLA)
Caruso, Raffaele…[et al.]. Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043417
American Medical Association (AMA)
Caruso, Raffaele& Campolo, Jonica& Verde, Alessandro& Botta, Luca& Cozzi, Lorena& Parolini, Marina…[et al.]. Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043417