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Differences in the Antigens of Helicobacter pylori Strains Influence on the Innate Immune Response in the In Vitro Experiments
Joint Authors
Skvarc, Miha
Kos, Janko
Obermajer, Natasa
Tepes, Bojan
Kopitar, Andreja Nataša
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The immune response to Helicobacter pylori importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria.
Strains of H.
pylori were gathered from 14 patients who failed to eradicate H.
pylori infection with antibiotics—therapy resistant strains (TRS)—or from patients who were able to eradicate H.
pylori infection—therapy susceptible strains (TSS).
The THP-1 cells were stimulated with H.
pylori antigens.
Cathepsin X expression on THP-1 cells and concentration of cytokines in the supernatant of THP-1 cells were measured with a flow cytometer.
TSS H.
pylori antigens increased the proportion of cathepsin X positive cells compared to TRS H.
pylori antigens.
TSS H.
pylori antigens induced higher secretion of IL-12 and IL-6 compared to TRS H.
pylori antigens ( P < 0.001 ; 0.02).
Polymyxin B, a lipid A inhibitor, lowered the secretion of IL-12 and IL-6 in TRS and TSS.
We demonstrated a H.
pylori strain-dependent cathepsin X and cytokine expression that can be associated with H.
pylori resistance to eradication due to lack of effective immune response.
Differences in lipid A of H.
pylori might have an influence on the insufficient immune response, especially on phagocytosis.
American Psychological Association (APA)
Skvarc, Miha& Kopitar, Andreja Nataša& Kos, Janko& Obermajer, Natasa& Tepes, Bojan. 2014. Differences in the Antigens of Helicobacter pylori Strains Influence on the Innate Immune Response in the In Vitro Experiments. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043421
Modern Language Association (MLA)
Skvarc, Miha…[et al.]. Differences in the Antigens of Helicobacter pylori Strains Influence on the Innate Immune Response in the In Vitro Experiments. Mediators of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043421
American Medical Association (AMA)
Skvarc, Miha& Kopitar, Andreja Nataša& Kos, Janko& Obermajer, Natasa& Tepes, Bojan. Differences in the Antigens of Helicobacter pylori Strains Influence on the Innate Immune Response in the In Vitro Experiments. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043421