Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury
Joint Authors
da Silva, João Santana
Camara, Niels Olsen Saraiva
Correa-Costa, Matheus
Braga, Tárcio Teodoro
Felizardo, Raphael José Ferreira
Andrade-Oliveira, Vinícius
Perez, Katia Regina
Cuccovia, Iolanda Midea
Hiyane, Meire Ioshie
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries.
In this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the absence of a proper regulation, can lead to fibrosis deposition.
Based on this perception, we evaluated the participation of macrophage recruitment in the development of TIN.
Initially, we provided adenine-enriched food to WT and searched for macrophage presence and action in the kidney.
Also, a group of animals were depleted of macrophages with the clodronate liposome while receiving adenine-enriched diet.
We collected blood and renal tissue from these animals and renal function, inflammation, and fibrosis were evaluated.
We observed higher expression of chemokines in the kidneys of adenine-fed mice and a substantial protection when macrophages were depleted.
Then, we specifically investigated the role of some key chemokines, CCR5 and CCL3, in this TIN experimental model.
Interestingly, CCR5 KO and CCL3 KO animals showed less renal dysfunction and a decreased proinflammatory profile.
Furthermore, in those animals, there was less profibrotic signaling.
In conclusion, we can suggest that macrophage infiltration is important for the onset of renal injury in the adenine-induced TIN.
American Psychological Association (APA)
Correa-Costa, Matheus& Braga, Tárcio Teodoro& Felizardo, Raphael José Ferreira& Andrade-Oliveira, Vinícius& Perez, Katia Regina& Cuccovia, Iolanda Midea…[et al.]. 2014. Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043463
Modern Language Association (MLA)
Correa-Costa, Matheus…[et al.]. Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043463
American Medical Association (AMA)
Correa-Costa, Matheus& Braga, Tárcio Teodoro& Felizardo, Raphael José Ferreira& Andrade-Oliveira, Vinícius& Perez, Katia Regina& Cuccovia, Iolanda Midea…[et al.]. Macrophage Trafficking as Key Mediator of Adenine-Induced Kidney Injury. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043463