The Inflammatory Chemokine CCL5 and Cancer Progression
Joint Authors
Aldinucci, Donatella
Colombatti, Alfonso
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Until recently, inflammatory chemokines were viewed mainly as indispensable “gate keepers” of immunity and inflammation.
However, updated research indicates that cancer cells subvert the normal chemokine system and these molecules and their receptors become important constituents of the tumor microenvironment with very different ways to exert tumor-promoting roles.
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers.
This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies aimed to inhibit the binding of CCL5 to CCR5, to inhibit CCL5 secretion, or to inhibit the interactions among tumor cells and the microenvironment leading to CCL5 secretion.
American Psychological Association (APA)
Aldinucci, Donatella& Colombatti, Alfonso. 2014. The Inflammatory Chemokine CCL5 and Cancer Progression. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043465
Modern Language Association (MLA)
Aldinucci, Donatella& Colombatti, Alfonso. The Inflammatory Chemokine CCL5 and Cancer Progression. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043465
American Medical Association (AMA)
Aldinucci, Donatella& Colombatti, Alfonso. The Inflammatory Chemokine CCL5 and Cancer Progression. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043465