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The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma
Joint Authors
Neunaber, C.
Pufe, T.
Klüter, Tim
Fitschen-Oestern, Stefanie
Lippross, Sebastian
Weuster, Matthias
Mentlein, Rolf
Steubesand, Nadine
Tohidnezhad, Mersedeh
Beyer, Andreas
Seekamp, Andreas
Varoga, Deike
Hildebrand, Frank
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The antimicrobial peptide lysozyme is an important factor of innate immunity and exerts high potential of antibacterial activity.
In the present study we evaluated the lysozyme expression in serum of multiple injured patients and subsequently analyzed their possible sources and signaling pathways.
Expression of lysozyme was examined in blood samples of multiple trauma patients from the day of trauma until 14 days after trauma by ELISA.
To investigate major sources of lysozyme, its expression and regulation in serum samples, different blood cells, and tissue samples were analysed by ELISA and real-time PCR.
Neutrophils and hepatocytes were stimulated with cytokines and supernatant of Staphylococcus aureus.
The present study demonstrates the induction and release of lysozyme in serum of multiple injured patients.
The highest lysozyme expression of all tested cells and tissues was detected in neutrophils.
Stimulation with trauma-related factors such as interleukin-6 and S.
aureus induced lysozyme expression.
Liver tissue samples of patients without trauma show little lysozyme expression compared to neutrophils.
After stimulation with bacterial fragments, lysozyme expression of hepatocytes is upregulated significantly.
Toll-like receptor 2, a classic receptor of Gram-positive bacterial protein, was detected as a possible target for lysozyme induction.
American Psychological Association (APA)
Klüter, Tim& Fitschen-Oestern, Stefanie& Lippross, Sebastian& Weuster, Matthias& Mentlein, Rolf& Steubesand, Nadine…[et al.]. 2014. The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043468
Modern Language Association (MLA)
Klüter, Tim…[et al.]. The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043468
American Medical Association (AMA)
Klüter, Tim& Fitschen-Oestern, Stefanie& Lippross, Sebastian& Weuster, Matthias& Mentlein, Rolf& Steubesand, Nadine…[et al.]. The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043468