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Association of Serum Tumor Necrosis Factor-Related Apoptosis Inducing Ligand with Body Fat Distribution as Assessed by Dual X-Rays Absorptiometry
Joint Authors
Secchiero, Paola
Celeghini, Claudio
Bonaccorsi, Gloria
Zauli, Giorgio
Cervellati, Carlo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A low chronic inflammation mediated by cytokine release is considered a major pathogenic mechanism accounting for the higher risk of cardiovascular disease in the overweight/obese population.
In this context, although the existence of a possible interaction between soluble tumor necrosis factor- (TNF-) related apoptosis inducing ligand (TRAIL) and quantity and localization, of adiposity in the body has been hypothesized, no studies have yet investigated this link by radiologic techniques able to assess directly fat mass (FM) in different body regions.
To address this issue, we assessed body fat distribution by dual X-rays absorptiometry (DXA) in a sample of 103 women and investigated the possible association between the derived adiposity measures and serum TRAIL concentration.
The level of TRAIL showed a positive and independent correlation with arms FM (P<0.05), trunk FM (P<0.001) and trunk FM% (P<0.05), total FM and total FM% (P<0.001 for both), and an inverse association with legs FM% (P<0.05).
Only trunk FM retained a significant correlation (P<0.05) with TRAIL after adjusting for all the other indices of regional adiposity.
In conclusion, from our study it emerged a significant and independent association of serum TRAIL levels with overall, and, mainly, central adiposity.
Further studies are needed to longitudinally investigate the cause-effect relationship between change in body fat distribution and TRAIL.
American Psychological Association (APA)
Cervellati, Carlo& Secchiero, Paola& Bonaccorsi, Gloria& Celeghini, Claudio& Zauli, Giorgio. 2014. Association of Serum Tumor Necrosis Factor-Related Apoptosis Inducing Ligand with Body Fat Distribution as Assessed by Dual X-Rays Absorptiometry. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043470
Modern Language Association (MLA)
Cervellati, Carlo…[et al.]. Association of Serum Tumor Necrosis Factor-Related Apoptosis Inducing Ligand with Body Fat Distribution as Assessed by Dual X-Rays Absorptiometry. Mediators of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043470
American Medical Association (AMA)
Cervellati, Carlo& Secchiero, Paola& Bonaccorsi, Gloria& Celeghini, Claudio& Zauli, Giorgio. Association of Serum Tumor Necrosis Factor-Related Apoptosis Inducing Ligand with Body Fat Distribution as Assessed by Dual X-Rays Absorptiometry. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043470