Active Smoking Increases Microsomal PGE2-Synthase-1PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms
Joint Authors
Vila, Luis
Dilmé, Jaime-Félix
Solà-Villà, David
Bellmunt, Sergi
Romero, José-María
Escudero, José-Román
Camacho, Mercedes
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans.
In this study, we investigated the influence of cardiovascular risk factors on the expression of the PGE 2 pathway in human AAA.
Methods.
Aortic ( n = 89 ) and plasma ( n = 79 ) samples from patients who underwent AAA repair were collected.
Patients were grouped according to risk factors.
COX-isoenzymes, mPGES-1, EPs, α-actin, and CD45 and CD68 transcripts levels were quantified by QRT-PCR and plasma PGE 2 metabolites by EIA.
Results.
Current smoking (CS) patients compared to no-CS had significantly higher local levels of mPGES-1 ( P = 0.009 ) , EP-4 ( P = 0.007 ) , and PGE 2 metabolites plasma levels ( P = 0.008 ) .
In the multiple linear regression analysis, these parameters remained significantly enhanced in CS after adding confounding factors.
Results from association studies with cell type markers suggested that the increased mPGES-1/EP-4 levels were mainly associated with microvascular endothelial cells.
Conclusions.
This study shows that elements of the PGE 2 pathway, which play an important role in AAA development, are increased in CS.
These results provide insight into the relevance of tobacco smoking in AAA development and reinforce the potential of mPGES-1 and EP-4 as targets for therapy in AAA patients.
American Psychological Association (APA)
Dilmé, Jaime-Félix& Solà-Villà, David& Bellmunt, Sergi& Romero, José-María& Escudero, José-Román& Camacho, Mercedes…[et al.]. 2014. Active Smoking Increases Microsomal PGE2-Synthase-1PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043475
Modern Language Association (MLA)
Dilmé, Jaime-Félix…[et al.]. Active Smoking Increases Microsomal PGE2-Synthase-1PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043475
American Medical Association (AMA)
Dilmé, Jaime-Félix& Solà-Villà, David& Bellmunt, Sergi& Romero, José-María& Escudero, José-Román& Camacho, Mercedes…[et al.]. Active Smoking Increases Microsomal PGE2-Synthase-1PGE-Receptor-4 Axis in Human Abdominal Aortic Aneurysms. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043475