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Purinergic Receptors in Ocular Inflammation
Joint Authors
Guzman-Aranguez, Ana
Gasull, Xavier
Diebold, Yolanda
Pintor, Jesús
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease.
When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ.
The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P1,P4-diadenosine tetraphosphate (Ap4A), and P1,P5-diadenosine pentaphosphate (Ap5A) are present in different ocular locations and therefore they may contribute/modulate inflammatory processes.
Adenosine receptors, in particular A2A adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation.
Regarding the A3 receptor, selective agonists like N6-(3-iodobenzyl)-5′-N-methylcarboxamidoadenosine (CF101) have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis.
Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases) can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues.
Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis.
In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes.
This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation.
American Psychological Association (APA)
Guzman-Aranguez, Ana& Gasull, Xavier& Diebold, Yolanda& Pintor, Jesús. 2014. Purinergic Receptors in Ocular Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043488
Modern Language Association (MLA)
Guzman-Aranguez, Ana…[et al.]. Purinergic Receptors in Ocular Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043488
American Medical Association (AMA)
Guzman-Aranguez, Ana& Gasull, Xavier& Diebold, Yolanda& Pintor, Jesús. Purinergic Receptors in Ocular Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043488