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Tumour Necrosis Factor Superfamily Members in the Pathogenesis of Inflammatory Bowel Disease
Joint Authors
Ślebioda, Tomasz J.
Kmieć, Zbigniew
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn’s disease (CD) and ulcerative colitis (UC).
CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in intestines and disruption of intestinal epithelial barrier.
Members of the tumour necrosis factor superfamily (TNFSF) are molecules of broad spectrum of activity, including direct disruption of intestinal epithelial barrier integrity and costimulation of proinflammatory functions of lymphocytes.
Tumour necrosis factor (TNF) has a well-established pathological role in IBD which also serves as a target in IBD treatment.
In this review we discuss the role of TNF and other TNFSF members, notably, TL1A, FasL, LIGHT, TRAIL, and TWEAK, in the pathogenesis of IBD.
American Psychological Association (APA)
Ślebioda, Tomasz J.& Kmieć, Zbigniew. 2014. Tumour Necrosis Factor Superfamily Members in the Pathogenesis of Inflammatory Bowel Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043490
Modern Language Association (MLA)
Ślebioda, Tomasz J.& Kmieć, Zbigniew. Tumour Necrosis Factor Superfamily Members in the Pathogenesis of Inflammatory Bowel Disease. Mediators of Inflammation No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1043490
American Medical Association (AMA)
Ślebioda, Tomasz J.& Kmieć, Zbigniew. Tumour Necrosis Factor Superfamily Members in the Pathogenesis of Inflammatory Bowel Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043490