Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial
Joint Authors
Rajkumar, Hemalatha
Mahmood, Naseha
Kumar, Manoj
Varikuti, Sudarshan Reddy
Challa, Hanumanth Reddy
Myakala, Shiva Prakash
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To evaluate the effects of probiotic (VSL#3) and omega-3 fatty acid on insulin sensitivity, blood lipids, and inflammation, we conducted a clinical trial in 60 overweight (BMI>25), healthy adults, aged 40–60 years.
After initial screening the subjects were randomized into four groups with 15 per group.
The four groups received, respectively, placebo, omega-3 fatty acid, probiotic VSL#3, or both omega-3 and probiotic, for 6 weeks.
Blood and fecal samples were collected at baseline and after 6 weeks.
The probiotic (VSL#3) supplemented group had significant reduction in total cholesterol, triglyceride, LDL, and VLDL and had increased HDL (P<0.05) value.
VSL#3 improved insulin sensitivity (P<0.01), decreased hsCRP, and favorably affected the composition of gut microbiota.
Omega-3 had significant effect on insulin sensitivity and hsCRP but had no effect on gut microbiota.
Addition of omega-3 fatty acid with VSL#3 had more pronounced effect on HDL, insulin sensitivity and hsCRP.
Subjects with low HDL, insulin resistance, and high hsCRP had significantly lower total lactobacilli and bifidobacteria count and higher E.
coli and bacteroides count.
American Psychological Association (APA)
Rajkumar, Hemalatha& Mahmood, Naseha& Kumar, Manoj& Varikuti, Sudarshan Reddy& Challa, Hanumanth Reddy& Myakala, Shiva Prakash. 2014. Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043496
Modern Language Association (MLA)
Rajkumar, Hemalatha…[et al.]. Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043496
American Medical Association (AMA)
Rajkumar, Hemalatha& Mahmood, Naseha& Kumar, Manoj& Varikuti, Sudarshan Reddy& Challa, Hanumanth Reddy& Myakala, Shiva Prakash. Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043496