Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models
Joint Authors
Xing, Dongqi
Hage, Fadi G.
Miller, Andrew
Oparil, Suzanne
Chen, Yiu-Fai
Mazzone, Michelle
Early, Richard
Henry, Scott P.
Zanardi, Thomas A.
Graham, Mark J.
Crooke, Rosanne M.
McCrory, Mark A.
Szalai, Alexander J.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Raised blood C-reactive protein (CRP) level is a predictor of cardiovascular events, but whether blood CRP is causal in the disease process is unknown.
The latter would best be defined by pharmacological inhibition of the protein in the context of a randomized case-control study.
However, no CRP specific drug is currently available so such a prospective study cannot be performed.
Blood CRP is synthesized primarily in the liver and the liver is an organ where antisense oligonucleotide (ASO) drugs accumulate.
Taking advantage of this we evaluated the efficacy of CRP specific ASOs in rodents with experimentally induced cardiovascular damage.
Treating rats for 4 weeks with a rat CRP-specific ASO achieved >60% reduction of blood CRP.
Notably, this effect was associated with improved heart function and pathology following myocardial infarction (induced by ligation of the left anterior descending artery).
Likewise in human CRP transgenic mice treated for 2 weeks with a human CRP-specific ASO, blood human CRP was reduced by >70% and carotid artery patency was improved (2 weeks after surgical ligation).
CRP specific ASOs might pave the way towards a placebo-controlled trial that could clarify the role of CRP in cardiovascular disease.
American Psychological Association (APA)
Szalai, Alexander J.& McCrory, Mark A.& Xing, Dongqi& Hage, Fadi G.& Miller, Andrew& Oparil, Suzanne…[et al.]. 2014. Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043500
Modern Language Association (MLA)
Szalai, Alexander J.…[et al.]. Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043500
American Medical Association (AMA)
Szalai, Alexander J.& McCrory, Mark A.& Xing, Dongqi& Hage, Fadi G.& Miller, Andrew& Oparil, Suzanne…[et al.]. Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043500