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Obesity and Low-Grade Inflammation Increase Plasma Follistatin-Like 3 in Humans
Joint Authors
Pedersen, Bente Klarlund
Brandt, Claus
Pedersen, Maria
Rinnov, Anders
Andreasen, Anne S.
Møller, Kirsten
Hojman, Pernille
Plomgaard, Peter
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity.
In humans, plasma fstl3 is reduced with gestational diabetes.
In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation.
Objective.
To elucidate the association between plasma fstl3 and obesity, insulin resistance, and low-grade inflammation in humans.
Study Design.
Plasma fstl3 levels were determined in a cross-sectional study including three groups: patients with type 2 diabetes, impaired glucose tolerance, and healthy controls.
In addition, lipopolysaccharide (LPS), TNF-α, or interleukin-6 (IL-6) as well as a hyperinsulinemic euglycemic clamp were used to examine if plasma fstl3 was acutely regulated in humans.
Results.
Plasma fstl3 was increased in obese subjects independent of glycemic state.
Moreover, plasma fstl3 was positively correlated with fat mass, plasma leptin, fasting insulin, and HOMA B and negatively with HOMA S.
Furthermore plasma fstl3 correlated positively with plasma TNF-α and IL-6 levels.
Infusion of LPS and TNF-α, but not IL-6 and insulin, increased plasma fstl3 in humans.
Conclusion.
Plasma fstl3 is increased in obese subjects and associated with fat mass and low-grade inflammation.
Furthermore, TNF-α increased plasma fstl3, suggesting that TNF-α is one of the inflammatory drivers of increased systemic levels of fstl3.
American Psychological Association (APA)
Brandt, Claus& Pedersen, Maria& Rinnov, Anders& Andreasen, Anne S.& Møller, Kirsten& Hojman, Pernille…[et al.]. 2014. Obesity and Low-Grade Inflammation Increase Plasma Follistatin-Like 3 in Humans. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043507
Modern Language Association (MLA)
Brandt, Claus…[et al.]. Obesity and Low-Grade Inflammation Increase Plasma Follistatin-Like 3 in Humans. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043507
American Medical Association (AMA)
Brandt, Claus& Pedersen, Maria& Rinnov, Anders& Andreasen, Anne S.& Møller, Kirsten& Hojman, Pernille…[et al.]. Obesity and Low-Grade Inflammation Increase Plasma Follistatin-Like 3 in Humans. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043507