The Antioxidant Profiles, Lysosomal and Membrane Enzymes Activity in Patients with Acute Pancreatitis
Joint Authors
Milnerowicz, Halina
Bukowski, Radosław
Jabłonowska, Monika
Ściskalska, Milena
Milnerowicz, Stanisław
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress and inflammatory mediators, such as IL-6, play an important role in the pathophysiology of acute pancreatitis.
The study was aimed to assess the degree of the pro/antioxidative imbalance and estimate which antioxidant plays a role in the maintenance of pro/antioxidative balance during acute pancreatitis.
The study was investigated in the blood of 32 patients with acute pancreatitis and 37 healthy subjects.
IL-6 concentration as early marker of inflammation was determinated.
The intensity of oxidative stress was assessed by TBARS concentration.
To investigate antioxidative status, the GPx and Cu/Zn SOD activities and the levels of GSH, MT, SH groups, and TRAP were measured.
The concentrations of Cu and Zn as ions participating in the maintenance of antioxidant enzymes stability and playing a role in the course of disease were determinated.
The activities of GGT, AAP, NAG, and β-GD as markers of tissue damage were also measured.
An increase in IL-6 concentration, which correlated with Ranson criteria, and an increase in GPx activity, levels of MT, TBARS, or GGT, and NAG activities in patients group compared to healthy subjects were demonstrated.
A decrease in GSH level in patients group compared to control group was noted.
The studies suggest that GPx/GSH and MT play the role of the first line of defence against oxidative stress and pro/antioxidant imbalance in the course of acute pancreatitis.
American Psychological Association (APA)
Milnerowicz, Halina& Bukowski, Radosław& Jabłonowska, Monika& Ściskalska, Milena& Milnerowicz, Stanisław. 2014. The Antioxidant Profiles, Lysosomal and Membrane Enzymes Activity in Patients with Acute Pancreatitis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043512
Modern Language Association (MLA)
Milnerowicz, Halina…[et al.]. The Antioxidant Profiles, Lysosomal and Membrane Enzymes Activity in Patients with Acute Pancreatitis. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043512
American Medical Association (AMA)
Milnerowicz, Halina& Bukowski, Radosław& Jabłonowska, Monika& Ściskalska, Milena& Milnerowicz, Stanisław. The Antioxidant Profiles, Lysosomal and Membrane Enzymes Activity in Patients with Acute Pancreatitis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043512