A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model
Joint Authors
Chi, Liqun
Gao, Wenyuan
Shu, Xiangrong
Lu, Xin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that causes deformity of the joints and physical disability.
Icariin, a natural flavonoid glucoside isolated from plants in the Epimedium family, has been proven to have various pharmacological activities.
A recent study showed that icariin suppressed cartilage and bone degradation in mice of collagen-induced arthritis.
However, the mechanism needs to be further investigated.
In our current study, we found that icariin reduced the arthritis score and the incidence of arthritis compared with that in mice treated with water.
Icariin inhibits the expression of various osteoclastogenic markers, such as β3 integrin, cathepsin K, and MMP9 in vitro.
Icariin treatment in mice with CIA also resulted in less number of Th17 cells and decreased ratio of CD4+IL-17+ cells.
The alleviated arthritis score and incidence of arthritis and reduced serum levels of IgG2a induced by icariin were abolished with additional IL-17 administration.
Furthermore, icariin inhibited STAT3 activation in T cells and STAT3 inhibitor resulted in decreased IL-17 production and alleviated RA.
In conclusion, icariin decreases Th17 cells and suppresses the production of IL-17, which contributes to the alleviated rheumatoid arthritis, through the inhibition of STAT3 activation.
American Psychological Association (APA)
Chi, Liqun& Gao, Wenyuan& Shu, Xiangrong& Lu, Xin. 2014. A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043534
Modern Language Association (MLA)
Chi, Liqun…[et al.]. A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043534
American Medical Association (AMA)
Chi, Liqun& Gao, Wenyuan& Shu, Xiangrong& Lu, Xin. A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043534