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Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses
Joint Authors
Das, Subhadip
Chatterjee, Nabanita
Bose, Dipayan
Banerjee, Somenath
Pal, Prajnamoy
Jha, Tarun
Das Saha, Krishna
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Sepsis is the reflection of systemic immune response that manifests in the sequential inflammatory process in presence of infection.
This may occur as a result of gram-negative bacterial sepsis including Escherichia coli infection that gives rise to excessive production of inflammatory mediators and causes severe tissue injuries.
We have reported earlier that the lipid of attenuated Leishmania donovani suppresses the inflammatory responses in arthritis patients.
Using heat killed E.
coli stimulated macrophages, we have now investigated the effect of leishmanial total lipid (LTL) isolated from Leishmania donovani (MHO/IN/1978/UR6) for amelioration of the inflammatory mediators and transcriptional factor with suppression of TLR4-CD14 expression.
To evaluate the in vivo effect, E.
coli induced murine sepsis model was used focusing on the changes in different parameter(s) of lung injury caused by sepsis, namely, edema, vascular permeability, and pathophysiology, and the status of different cytokine-chemokine(s) and adhesion molecule(s).
Due to the effect of LTL, E.
coli induced inflammatory cytokine-chemokine(s) levels were significantly reduced in serum and bronchoalveolar lavage fluid simultaneously.
LTL also improved the lung injury and suppressed the cell adhesion molecules in lung tissue.
These findings indicate that LTL may prove to be a potential anti-inflammatory agent and provide protection against gram-negative bacterial sepsis with pulmonary impairment.
American Psychological Association (APA)
Das, Subhadip& Chatterjee, Nabanita& Bose, Dipayan& Banerjee, Somenath& Pal, Prajnamoy& Jha, Tarun…[et al.]. 2014. Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043542
Modern Language Association (MLA)
Das, Subhadip…[et al.]. Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses. Mediators of Inflammation No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1043542
American Medical Association (AMA)
Das, Subhadip& Chatterjee, Nabanita& Bose, Dipayan& Banerjee, Somenath& Pal, Prajnamoy& Jha, Tarun…[et al.]. Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043542