Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women
Joint Authors
Lapointe, Marc
Poursharifi, Pegah
Rezvani, Reza
Marceau, Picard
Gupta, Abhishek
Tchernof, André
Cianflone, Katherine
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Adipose tissue receptors C5aR and C5L2 and their heterodimerization/functionality and interaction with ligands C5a and acylation stimulating protein (ASP) have been evaluated in cell and rodent studies.
Their contribution to obesity factors in humans remains unclear.
We hypothesized that C5a receptors, classically required for host defense, are also associated with adiposity.
Anthropometry and fasting blood parameters were measured in 136 women divided by body mass index (BMI): normal/overweight (≤30 kg/m2; n = 34), obese I (≤45 kg/m2; n = 33), obese II (≤51 kg/m2; n = 33), and obese III (≤80 kg/m2; n = 36).
Subcutaneous and omental adipose tissue C5aR and C5L2 expression were analysed.
C5L2 expression was comparable between subcutaneous and omental across all BMI groups.
Plasma ASP and ASP/omental C5L2 expression increased with BMI (P < 0.001 and P < 0.01, resp.).
While plasma C5a was unchanged, C5aR expression decreased with increasing BMI in subcutaneous and omental tissues (P < 0.01 and P < 0.05, resp.), with subcutaneous omental depots.
Omental C5L2/C5aR ratio increased with BMI (P < 0.01) with correlations between C5L2/C5aR and waist circumference, HDL-C, and adiponectin.
Tissue and BMI differences in receptors and ligands, particularly in omental, suggest relationship to metabolic disturbances and highlight adipose-immune interactions.
American Psychological Association (APA)
Poursharifi, Pegah& Rezvani, Reza& Gupta, Abhishek& Lapointe, Marc& Marceau, Picard& Tchernof, André…[et al.]. 2014. Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043546
Modern Language Association (MLA)
Poursharifi, Pegah…[et al.]. Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043546
American Medical Association (AMA)
Poursharifi, Pegah& Rezvani, Reza& Gupta, Abhishek& Lapointe, Marc& Marceau, Picard& Tchernof, André…[et al.]. Association of Immune and Metabolic Receptors C5aR and C5L2 with Adiposity in Women. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043546