![](/images/graphics-bg.png)
Protective Effect of Laminaria japonica with Probiotics on Murine Colitis
Joint Authors
Park, Jae-Woo
Bu, Youngmin
Lee, Beom-Joon
Bae, Jinhyun
Bang, Yu-mi
Lee, Hyejung
Kim, Jinsung
Yoo, Hye Hyun
Ko, Seok-Jae
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract.
Most IBD treatments are unsatisfactory; therefore, various dietary supplements have emerged as promising interventions.
Laminaria japonica (LJ) is an edible seaweed used to regulate digestive symptoms.
Probiotics have been reported to improve digestive problems and their simultaneous administration with seaweeds has been shown to produce synergistic therapeutic effects.
Here, we investigated the effect of LJ combination with probiotics on dextran sodium sulfate-induced colitis model in mice.
Aqueous LJ extracts (LJE) at doses from 100 to 300 mg/kg and probiotics at a dose of 300 mg/kg were orally administered for 7 days.
Body weight, colon length, histological score, macroscopic damage, and the levels of cytokines IFN-γ, IL-1β, IL-6, IL-10, IL-12 (P40), IL-12 (P70), IL-17, and TNF-α were assessed.
LJE alone caused a significant improvement of colitis signs such as colon length, histological score, and IL-1β and IL-6 production.
LJE and probiotics demonstrated a synergistic effect by the histological score and levels of IL-1β, IL-6, and IL-12 (P40) but not IFN-γ, IL-10, and IL-12 (P70).
In conclusion, LJE was effective in inducing protection against colitis in mice and acted synergistically with probiotics.
American Psychological Association (APA)
Ko, Seok-Jae& Bu, Youngmin& Bae, Jinhyun& Bang, Yu-mi& Kim, Jinsung& Lee, Hyejung…[et al.]. 2014. Protective Effect of Laminaria japonica with Probiotics on Murine Colitis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043547
Modern Language Association (MLA)
Ko, Seok-Jae…[et al.]. Protective Effect of Laminaria japonica with Probiotics on Murine Colitis. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043547
American Medical Association (AMA)
Ko, Seok-Jae& Bu, Youngmin& Bae, Jinhyun& Bang, Yu-mi& Kim, Jinsung& Lee, Hyejung…[et al.]. Protective Effect of Laminaria japonica with Probiotics on Murine Colitis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043547