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Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model
Joint Authors
Ku, Jin Mo
Ko, Seong-Gyu
Kim, Soon Re
Shin, Yong Cheol
Hong, Se Hyang
Choi, Han-Seok
Seo, Hye-Sook
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Allergic rhinitis (AR) is an allergic inflammation of the nasal airways.
The prevalence of AR is increasing worldwide.
We investigated whether Hyeonggaeyeongyo-tang (HYT) is effective to suppress the progression of AR induced by ovalbumin (OVA).
Male BALB/c mice were used for this study.
Allergic rhinitis was induced by OVA.
Treatment with HYT was assessed to study the effect of HYT on allergic rhinitis in mice.
Histological analysis, immunohistochemistry, multiplex cytokine assay, blood analysis, and cell viability assay were performed to verify inhibitory effect of HYT on allergic rhinitis.
HYT did not show any toxicity maintaining body weight.
Food intake was steady without variation in mice.
HYT reduced infiltration of inflammatory cells and mast cells into nasal cavity.
HYT reduced the levels of cytokines and leukocytes in the blood.
HYT decreased the splenocyte cell viability.
Antihistamines and steroids are the most common medications used to treat allergic rhinitis.
However, long-term use of drug generates resistance or side effects requiring the development of new drug.
Our present study clearly demonstrates that HYT suppresses the progression of allergic rhinitis induced by OVA.
This suggests that HYT might be a useful drug for the treatment of allergic rhinitis.
American Psychological Association (APA)
Hong, Se Hyang& Kim, Soon Re& Choi, Han-Seok& Ku, Jin Mo& Seo, Hye-Sook& Shin, Yong Cheol…[et al.]. 2014. Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043550
Modern Language Association (MLA)
Hong, Se Hyang…[et al.]. Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043550
American Medical Association (AMA)
Hong, Se Hyang& Kim, Soon Re& Choi, Han-Seok& Ku, Jin Mo& Seo, Hye-Sook& Shin, Yong Cheol…[et al.]. Effects of Hyeonggaeyeongyo-Tang in Ovalbumin-Induced Allergic Rhinitis Model. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043550