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Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection
Joint Authors
Qu, Xin
Liu, Siguan
Liu, Feng
Wang, Chunting
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
The long pentraxin 3 (PTX3) is a key component of the humoral arm of the innate immune system.
PTX3 is produced locally in response to proinflammatory stimuli.
We reviewed the usefulness of systemic levels of PTX3 in critically ill patients with systemic inflammatory response syndrome (SIRS), sepsis, and bacteremia, focusing on its diagnostic and prognostic value.
Methods.
A PubMed search on PTX3 was conducted.
The list of papers was narrowed to original studies of critically ill patients.
Eleven papers on original studies of critically ill patients that report on PTX3 in SIRS, sepsis, or bacteremia were identified.
Results.
Systematic levels of PTX3 have little diagnostic value in critically ill patients with SIRS, sepsis, or bacteremia.
Systemic levels of PTX3, however, have superior prognostic power over other commonly used biological markers in these patients.
Systemic levels of PTX3 correlate positively with markers of organ dysfunction and severity-of-disease classification system scores.
Finally, systemic levels of PTX3 remain elevated in the acute phase and decreased on recovery.
Notably, the age of the patients and underlying disease affect systemic levels of PTX3.
Conclusions.
The diagnostic value of PTX3 is low in patients with sepsis.
Systemic levels of PTX3 have prognostic value and may add to prognostication of patients with SIRS or sepsis, complementing severity-of-disease classification systems and other biological markers.
American Psychological Association (APA)
Liu, Siguan& Qu, Xin& Liu, Feng& Wang, Chunting. 2014. Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043551
Modern Language Association (MLA)
Liu, Siguan…[et al.]. Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043551
American Medical Association (AMA)
Liu, Siguan& Qu, Xin& Liu, Feng& Wang, Chunting. Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043551